How Tocotrienol Fight Against
Leukemia Cancel Cells ?
Leukemia or blood cancer is one of the deadliest cancers with a survival rate of only 61.4% for just 5 years as stated in a report by National Cancer Institute, USA! Very few patients survive for more than 10 years only due to the common reoccurrence of this cancer. Conventional treatment modalities for cancer including surgery, radiation, and chemotherapy have failed to eradicate cancer entirely. To bring a better solution against such deadly disease, researchers and doctors have discovered natural anti-oxidants in the form of Annatto based Tocotrienolwhich can also be used with other chemotherapeutic drugsthat exhibit strong anti-cancer activities and one of these kinds of research is Gamma-Tocotrienol and Simvastatin Synergistically Induce Cytotoxicity In Leukemia Cell Lines, K-562 and HL-60 where it was observed that Gamma-Tocotrienol, an isoform of Vitamin E, and simvastatin, a cholesterol lowering drug exhibit synergy in induction of cytotoxicityin K-562 and HL-60 leukemia cell lines. Eannatto, has successfully harvested Annatto for Tocotrienolsrich in all its isoforms to help Leukemia patients throughout the globe in their fight against blood cancer.
Antioxidants, especially Tocotrienol was observed to exhibit anti-cancer activity against brain cancer cells.
Angiogenesis which is the process of formation of blood vessels in cancer cells like in your brain cancer. Tocotrienol promotes cancer cell death to a very great extent and good results of anti-angiogenesis property of Tocotrienols have been observed against blood cancer cells in the study.
Apoptosis or programmed cell death is the process of elimination and death of cancer cells. Reports have indicated that Delta-Tocotrienol and Gamma-Tocotrienol have been observed to induce apoptosis in leukemia cells in vitro via nuclear chromatin condensation and nuclear fragmentation. According to studies, it has also been observed that Gamma-Tocotrienol induced apoptosis in leukemia cells by inhibiting NF-kB, activating the caspase cascade, increasing cyt.c release and nuclear fragmentation.
Cell Proliferation is the process by which cancer cells copy their DNA and divide into two cancer cells during mitosis and rapidly multiply into more cancer cells. Tocotrienol isoforms have been observed to suppress cell proliferation. .
Chemoprevention and anti-cancer activity against Leukemia have been observed in Tocotrienols.
Chemosensitization is the combination of Tocotrienol with several chemotherapeutic drugs such as celecoxib, statins or dietary components such as curcumin, polyphenols, etc. A combination of simvastatin and Gamma-Tocotrienol induce cytotoxicity and exhibit synergy in leukemia cells.
The cytotoxic effect has been observed to be exerted against human T-cell lymphoblastic leukemia cells by the three isomers of Alpha-Tocotrienol, Gamma-Tocotrienol, and Delta-Tocotrienol.
Around 200-900 mg/day of Tocotrienols have been used to treat different kinds of cancers without any adverse effects and with good results.
Why Tocotrienol and Not Tocopherol?
Tocopherol has been observed to attenuate lung cancer inhibition, inhibits absorption, reduces adipose storage, and compromises cholesterol and triglyceride reduction. Tocopherol hinders the functioning of Tocotrienol and even when they are consumed simultaneously, Tocopherol obstructs all the functions of Tocotrienol.
Tocotrienol, the protector of State: Tocotrienol has more mobility than Tocopherol due to its small structure so it can cover a larger area targeting more number of lung cancer cells.
Small structure and less molecular weight: The higher anti-oxidant activity of Tocotrienols is due to their small structure and less molecular weight which assist in their integration of the cell, unlike Tocopherols.
Tocopherol, the antagonist in liver cancer treatment: It has been observed that Tocopherol not only interfered with the functioning of Tocotrienol but also showed harmful effects during the treatment.
Read Other Studies:
- Tocotrienols: The Promising Analogues of Vitamin E for Cancer Therapeutics https://doi.org/10.1016/j.phrs.2018.02.017
- Gamma-Tocotrienol and Simvastatin Synergistically Induce Cytotoxicity In Leukemia Cell Lines, K-562 and HL-60http://www.bloodjournal.org/content/122/21/4927?sso-checked=true
- National Cancer Institute, Cancer Stat Facts: Leukemia https://seer.cancer.gov/statfacts/html/leuks.html