The evidence to date: A redox-inactive analogue of tocotrienol as a new anti-mesothelioma agent

Investigating the Pro-apoptotic, Anti-Cell Proliferation, and Cytotoxic effects of a redox-inactive derivative of Tocotrineol.

The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human breast cancer cells, kindly refer to the reference link provided at the bottom of this abstract.

DELTA-TOCOTRIENOLS CAN SUPPORT

INHIBITION OF CELL PROLIFERATION
ATTENUATION OF TUMOR INVASION AND METASTASIS
INCREASE OF miR-451 EXPRESSIONS
REPRESSED EXPRESSION OF MMP-9 &Upa PROTEINS

Vitamin E has been one of the most prominent antioxidants of all time. Tocopherols, a group of fours isoforms of Vitamin E, has been consumed to a large scale till date. But, in several latest studies and research, it has been observed that Tocotrienols, which is the other group of the four isoforms of Vitamin E have incredible anticancer, antioxidant, and anti-inflammatory benefits!

Introduction to Mesothelioma and Tocotrienol

Malignant Mesothelioma (MM) is a very aggressive cancer and usually occurs in people who have been exposed to asbestos for a long period of time. It is formed in the lining of the abdomen, lungs, and heart. Although restrictions have been placed on asbestos, yet the cases have been increasing owing to its long latency period. It has been estimated that 3000 people in the United States are diagnosed with Mesothelioma each year and the chances of survival are very low for the next five years from the time of prognosis.

In this study, a new redox-derivative of Tocotrienol, 6-O-carboxypropyl-α-Tocotrienol to investigate its anti-cancer properties on Mesothelioma cells. The redox derivative of Tocotrienol was introduced to investigate its ability induce strong cytotoxicity on MM cells. Hence, in this study, the focus has been laid on the several anticancer effects like induction of apoptosis, anti-cell proliferation, and cytotoxicity of the redox derivative of Tocotrienol.

How does the Redox Derivative Tocotrienol fight Mesothelioma?

In this research, the anti-proliferative effects of Tocotrienol on human malignant mesothelioma cancer cells were discovered. It was observed that Tocotrienols suppress both the activity and expression of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase which results in suppression of cancer promoting functions like angiogenesis and cell proliferation.

MM cells have been observed to have chemo-resistance against cisplatin but when treated with Tocotrienols, the growth of the cancer cells was suppressed! Moreover, the cytotoxic effects of the redox derivative of Tocotrienols on the cancer cells was incredible.

It was also observed in the study that the Tocotrienols suppressed the blood supply to the tumor thus preventing the expansion of the tumor mass by inducing anti-angiogenesis and apoptosis in the cancer cells.

Suggested Usage:

EannattoDeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-900g of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer.

Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.

Reference for the Study in detail:
  1. https://www.rarediseasesjournal.com/articles/the-evidence-to-date-a-redoxinactive-analogue-of-tocotrienol-as-a-new-antimesothelioma-agent-raredis-1-1072.php
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The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human breast cancer cells, kindly refer to the reference link provided at the bottom of this abstract.