Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Investigating a novel function of Vitamin E Delta-Tocotrienol (VEDT) with TRAIL of inducing apoptosis in Pancreatic Cancer Cells.
The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human pancreatic cancer cells, kindly refer to the reference link provided at the bottom of this abstract.

DELTA-TOCOTRIENOLS CAN SUPPORT

INHIBITION OF CELL PROLIFERATION
ATTENUATION OF TUMOR INVASION AND METASTASIS
INCREASE OF miR-451 EXPRESSIONS
REPRESSED EXPRESSION OF MMP-9 &Upa PROTEINS
Vitamin E Delta-Tocotrienol (VEDT) can be extracted in their purest forms from the seeds of the Annatto plant. VEDT has been reported to have incredible antioxidant, anti-inflammatory, and anticancer properties. In several studies and research, VEDT has demonstrated to have therapeutic and chemopreventive effects, and hence in this study, VEDT has been investigated for its effects against pancreatic cancer.

Introduction to Pancreatic Cancer and Delta-Tocotrienol

There are several kinds of pancreatic cancer like pancreatic adenocarcinoma, ampullary cancer, and so on. It has been estimated that in the United States of America, in 2020 alone, 24,640 men and 22,410 women will be diagnosed with pancreatic cancer and around 47,050 people will die due to this disease.The worrisome fact regarding this cancer is that it is very difficult to diagnose because this cancer has no symptoms. If found at the early stages, then the tumor can be removed and the life expectancy can be increased but since the prognosis isn’t easy, cancer spreads quite fast, and hence, the 5-year survival rate is just 9%.

In this study, a novel function of Delta-Tocotrienol in augmenting tumor necrosis factor-related apoptosis-inducing gland (TRAIL) induced apoptosis or programmed cell death in pancreatic cancer cells was demonstrated. 

How does the Delta-Tocotrienol fight Pancreatic cancer?

It was observed in the study that, when VEDT was combined with TRAIL, it significantly augmented TRAIL-induced apoptosis in the pancreatic cancer cells. Delta-Tocotrienols was also observed to significantly decrease the cellular FLICE inhibitory protein (c-FLIP) levels. It has been observed that the expression of c-FLIP suppresses the apoptosis mechanism induced by the combination of VEDT and TRAIL. Hence, the reduction of c-FLIP expression is very necessary.

Also, it was demonstrated that Delta-Tocotrienol increased c-FLIP degradation and ubiquitination without affecting its transcription. Hence, it can be concluded that Delta-Tocotrienol decreases c-FLIP levels while degrading it.

Suggested Usage:
EannattoDeltaGold Tocotrienol contains 90% Delta-Tocotrienol and 10% Gamma-Tocotrienol. One bottle of Eannatto Tocotrienols contains 125g, 60 gels. In studies, 400-1600mg of dosage of Tocotrienols, have been suggested by researchers for patients suffering from cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil. cancer. Eannatto Tocotrienol has been derived from the Annatto plant, found in the Amazon which is 100% Tocopherol free. Also, Annatto contains 2x more Tocotrienols than Palm oil and 3x more Tocotrienols than rice bran oil.
Reference for the Study in detail:
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The following abstract is taken from a published study and is explained in simple terms to help you understand better. For deeper and technical insights regarding the action of Tocotrienols on human breast cancer cells, kindly refer to the reference link provided at the bottom of this abstract.