DELTA-TOCOTRIENOLS CAN SUPPORT
INHIBITION OF CELL PROLIFERATION
ATTENUATION OF TUMOR INVASION AND METASTASIS
INCREASE OF miR-451 EXPRESSIONS
REPRESSED EXPRESSION OF MMP-9 &Upa PROTEINS
Introduction to Pancreatic Cancer and Delta-Tocotrienol
There are several kinds of pancreatic cancer like pancreatic adenocarcinoma, ampullary cancer, and so on. It has been estimated that in the United States of America, in 2020 alone, 24,640 men and 22,410 women will be diagnosed with pancreatic cancer and around 47,050 people will die due to this disease.The worrisome fact regarding this cancer is that it is very difficult to diagnose because this cancer has no symptoms. If found at the early stages, then the tumor can be removed and the life expectancy can be increased but since the prognosis isn’t easy, cancer spreads quite fast, and hence, the 5-year survival rate is just 9%.
In this study, a novel function of Delta-Tocotrienol in augmenting tumor necrosis factor-related apoptosis-inducing gland (TRAIL) induced apoptosis or programmed cell death in pancreatic cancer cells was demonstrated.
How does the Delta-Tocotrienol fight Pancreatic cancer?
It was observed in the study that, when VEDT was combined with TRAIL, it significantly augmented TRAIL-induced apoptosis in the pancreatic cancer cells. Delta-Tocotrienols was also observed to significantly decrease the cellular FLICE inhibitory protein (c-FLIP) levels. It has been observed that the expression of c-FLIP suppresses the apoptosis mechanism induced by the combination of VEDT and TRAIL. Hence, the reduction of c-FLIP expression is very necessary.
Also, it was demonstrated that Delta-Tocotrienol increased c-FLIP degradation and ubiquitination without affecting its transcription. Hence, it can be concluded that Delta-Tocotrienol decreases c-FLIP levels while degrading it.
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